The Human-Trial Standard for Dietary Supplements
SupplementDecoded was established to dismantle the marketing fluff of the $180B global supplement industry. We extract therapeutic dosage thresholds, bioavailability kinetics, and heavy metal safety screens directly from published RCTs — with zero sponsor funding, zero affiliate links, and zero pay-to-play reviews.
Why Standard Supplement Marketing Cannot Be Trusted
Under the U.S. Dietary Supplement Health and Education Act of 1994 (DSHEA) and similar frameworks globally, dietary supplements are not required to demonstrate clinical efficacy prior to reaching consumer shelves. Manufacturers do not submit prospective Phase III human trials to the FDA before selling products.
This legal structure creates an environment where:
How SupplementDecoded Evaluates Ingredients
We operate as an independent clinical research and monograph desk. Every monograph in our database is constructed from the ground up by reviewing primary trial data indexed in PubMed, the Cochrane Library, and academic pharmacology repositories.
Our Editorial Independence Charter
Financial independence is the only guarantee of scientific integrity in dietary supplement research.
No Affiliate Tracking
We never use Amazon Associates, reward links, or retailer checkout cookies. Links point to PubMed DOIs and clinical registries.
No Sponsored Reviews
Brands cannot pay for expedited monograph reviews, favorable grades, or promotional placement. Every review is independent.
Editorial Team Reviewed
Our monographs are fact-checked by our research editorial team with backgrounds in pharmacology, pharmacognosy, and clinical biochemistry.
Living Evidence Base
When new multi-center human trials contradict older findings, our monographs are revised and version-stamped immediately.
Our 5-Tier Evidence Evaluation Scale
How our editorial team grades research quality and therapeutic plausibility.
Systematic Reviews & Meta-Analyses
Multiple high-quality human RCTs with consistent endpoints, robust sample sizes (>100 subjects), and low risk of funding bias.
Independent Human Clinical Trials
Double-blind, placebo-controlled human studies measuring direct physiological outcomes rather than subjective questionnaires.
Small Human Pilots & Observational Data
Preliminary human trials with small cohorts (<30 subjects) or short durations. Noted transparently as inconclusive.
Animal & In Vitro Proxies
Rodent or cell-culture mechanisms. Reported solely for biological plausibility; strictly forbidden from supporting human dosing claims.
Manufacturer Whitepapers & Influencer Claims
In-house brand studies, undisclosed proprietary blends, and paid testimonials carry zero evidential standing in our monographs.
Institutional Governance & Review Standards
Explore the detailed methodology documentation governing our scientific publishing process.
Editorial Policy
Our independent charter, conflict-of-interest guidelines, and source verification hierarchy.
Fact-Checking Process
How each monograph undergoes multi-stage editorial review and human RCT verification.
Scam & Whistleblower Desk
Confidential triage for reporting tainted batches, fake COAs, or undisclosed prescription drugs.
Medical Disclaimer
Regulatory definitions separating public research syntheses from individual medical treatment.
Explore the Clinical Monograph Database
Search peer-reviewed trials, therapeutic dosing ranges, and safety screens across our dietary supplement research monographs.